Nanosafety-data-reusability-34-datasets

Cytotoxicity analysis of nanoparticles by association rule mining (2021)

Original Study Abstract

Understanding the toxicity behavior of NPs is of great importance to ensure efficient delivery to intracellular targets without causing cytotoxicity, to measure the long-term effects of nanoparticles (NPs), and to predict risks and hazards to humans and the environment. However, the diversity and complexity of toxicity sample space, individual sampling, and missing/unreported information make it burdensome to draw general conclusions from the whole picture. To overcome the challenges of safe-by-design of NPs, here we create a machine learning approach by knowledge extraction from the literature which is based on the published toxicity data of inorganic, organic and carbon-based NPs. By integrating 15 qualitative and 10 quantitative attributes from 152 articles, we have obtained 4111 instances reflecting the toxicity of NPs with various material, cell, and experimental properties. Implementing association rule mining (ARM), we present that cytotoxicity is primarily related to the core and coating material of NPs, their synthesis route and the exposed cell type. Our model addresses the interdependence of attributes by shedding light on hidden relationships and we claim that it may contribute to the controlled and safe design of NPs in future studies.

Data Sample

No Year Material Type Shape Coat/Functional Group Synthesis_Method Surface_Charge Diameter (nm) Size_in_Water (nm) Size_in_Medium (nm) Zeta_in_Water (mV) Zeta_in_Medium (mV) Cell_Type No_of_Cells (cells/well) Human_Animal Cell_Source Cell_Tissue Cell_Morphology Cell_Age Cell Line_Primary Cell Time (hr) Concentration (ug/ml) Test Test_Indicator Aspect_Ratio Cell_Viability (%) PDI Article_ID DOI
1 2015 SiO2 I Sphere CTAB Precipitation Negative   386,9 90,09 -35,9   PC12 5000 A Rat Adrenal Gland Irregular Adult L 12 1,95 MTT TetrazoliumSalt   113,67   1 10.3109/15376516.2015.1070229
2 2015 SiO2 I Sphere CTAB Precipitation Negative   386,9 90,09 -35,9   PC12 5000 A Rat Adrenal Gland Irregular Adult L 12 3,9 MTT TetrazoliumSalt   97,265   1 10.3109/15376516.2015.1070229
3 2015 SiO2 I Sphere CTAB Precipitation Negative   386,9 90,09 -35,9   PC12 5000 A Rat Adrenal Gland Irregular Adult L 12 7,8 MTT TetrazoliumSalt   108,73   1 10.3109/15376516.2015.1070229
4 2015 SiO2 I Sphere CTAB Precipitation Negative   386,9 90,09 -35,9   PC12 5000 A Rat Adrenal Gland Irregular Adult L 12 15,6 MTT TetrazoliumSalt   98,451   1 10.3109/15376516.2015.1070229
5 2015 SiO2 I Sphere CTAB Precipitation Negative   386,9 90,09 -35,9   PC12 5000 A Rat Adrenal Gland Irregular Adult L 12 31,2 MTT TetrazoliumSalt   98,056   1 10.3109/15376516.2015.1070229

Data Summary

Variable Count (unique values)
Year 11
Material 35
Type 3
Shape 16
Coat/Functional Group 45
Synthesis_Method 27
Cell_Type 92
Human_Animal 2
Cell_Source 10
Cell_Tissue 32
Cell_Morphology 14
Cell_Age 3
Cell Line_Primary Cell 2
Time (hr) 13
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